Enhancement of Solubility of Rilpivirine by Inclusion Complexation with Cyclodextrins
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چکیده
منابع مشابه
Aqueous Solubility Enhancement of Some Flavones by Complexation with Cyclodextrins
The inclusion complexes of cyclodextrins (CDs) with flavones in aqueous solution were investigated by phase solubility measurements. The effect of β-cyclodextrin (β-CD), heptakis (2,6-di-O-methyl) β-cyclodextrin (DM-β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) on the aqueous solubility of three flavones, namely, chrysin, apigenin and luteolin was investigated, respectively. Solubility enh...
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Carvedilol is an effective nonselective alpha-1 and beta blocker discovered by Fritz Wiedemann [1] . It is an antihypertensive drug indicated for the treatment of mild to severe congestive heart failure (CHF), angina pectoris, cardiac arrhythmias and myocardial infarction [2] . Water solubility of Carvedilol is a fundamental property that affects the drug absorption after oral administration. M...
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A high dosage of albendazole (ABZ) is required for treating systemic helminthe infections because of its low solubility. Aiming at increasing ABZ solubility, complexation with beta-cyclodextrin ( -CD) using aqueous and acetic acid solutions as ABZ solubilizer was studied. In aqueous -CD, complexation increased solubility 53.4 times, giving a complex equilibrium constant of 1266 L mol with a max...
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Domperidone Maleate (DOM), an antiemetic drug, has been used in treatment of adults and children. It has low aqueous solubility and hence low bioavailability. In present study, an attempt has been made to enhance the solubility of DOM by inclusion complexation with Hydroxypropyl-βCyclodextrin (HP-β-CD) using kneading technique and formulation of fast disintegrating tablets by using Sodium Starc...
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Aqueous solubility is a critical factor for optimum drug delivery. In the present study, we investigated the potential of drugcyclodextrin complexation as an approach for improving the solubility and bioavailability of famotidine, an H2-receptor antagonist and acid reducing drug which has poor solubility and bioavailability. Solubility improvement of drug by βcyclodextrin was done by simple com...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutical Sciences and Drug Research
سال: 2018
ISSN: 0975-248X
DOI: 10.25004/ijpsdr.2018.100106